They are painless and there are normally no other problems or symptoms. The registry was established in 2007 to learn more about morphea. Morphea is an inflammatory disease of the dermis and subcutaneous tissue. It is a form of scleroderma patches most often occur on the abdomen, stomach. Disease bioinformatics research of generalized morphea has been linked to scleroderma, diffuse scleroderma, morphea, localized scleroderma, sclerosis. European dermatology forum s1guideline on the diagnosis and treatment of sclerosing diseases of the skin, part 1. Please tell us where you read or heard it including the quote, if possible. The symptoms of morphea subside on its own within 3 to 5 years of time. Histopathological changes in morphea and their clinical correlates. Adequate studies on the incidence and prevalence have not been performed. Morphea is a localized form of scleroderma that leads to excessive deposits of collagen in the skin, resulting in a thickening of the dermis and subcutaneous tissue. Morphean a swiss, high tech software development company. Software has a map of versions which key is the version codename. In addition to our lexicographic work, framenet has also annotated some continuous texts, mainly as a demonstration.
Genetic architecture of linear localized scleroderma zurich open. Jun 24, 20 two categories of scleroderma are known. Now customize the name of a clipboard to store your clips. However morphea can occur in a generalized form as well as guttate, nodular, subcutaneous and linear forms.
Morphea tends to affect only the outer layers of your skin. Morefeeah, is a fictional character published by dc comics. May, 20 my morphea spread pretty quickly in those first 6 months. Morphea morfeeuh is a rare skin condition that causes painless, discolored patches on your skin. The condition is rare and thought to affect less than 3 out of. Morphea genetic and rare diseases information center. Morphea is a term used to describe the skin symptoms of localized scleroderma, although the terms sometimes are used interchangeably while it can occur in all age groups, it is more common among adults. How do you define a field, eg email as having an index using jpa annotations. Morphea usually subsides on its own over time, though recurrences are common. Nested casecontrol study, conducted at the university of texas southwestern medical center, dallas, and university of texas health science center, houston. It most commonly affects the trunk but also occurs on the face and extremities. Because morphea affects your appearance, it can be an especially difficult condition to live with.
Here are links to possibly useful sources of information about morphea. It is based on a c library named libgenometools which consists of several modules. Morphea 6593ab7, usually simply called morphea pronunciation. Disease activity typically persists for three to six years, although some patients develop more persistent or recurring episodes of activity. If you have problems viewing pdf files, download the latest version of adobe reader. More detailed information about the symptoms, causes, and treatments of morphea is. The word scleroderma means hard skin and in localised scleroderma, fat, fascia, muscle and bone may also be affected but not internal organs as in systemic scleroderma. Morphea definition at, a free online dictionary with pronunciation, synonyms and translation. Linear morphea commonly affects the underlying muscle, bone, and if on the head the brain and is therefore treated aggressively. Morphea is an autoimmune disease that causes sclerosis, or scarlike, changes to the skin autoimmune diseases occur when the immune system, which normally protects us from bacteria, viruses, and fungi, mistakenly attacks a persons own body. Nov 10, 2016 localised scleroderma, also called morphoea or morphea, is a disorder of excessive collagen deposition leading to thickening of the dermis and sometimes the subcutaneous tissues.
Morphea story listings in english from the nonprofit international. Morphea is an uncommon condition that is thought to affect 2 to 4 in 100,000 people. Im pretty new to morphia and struggling with getting the index annotation to work. Oasis stands for open annotation semantic imaging system, a software application that lets you dive deep inside any image to. Morphea definition of morphea by the free dictionary. Its a good idea to avoid long, hot showers or baths, as these can dry your skin. Morphea is a skin condition that involves a patch or patches of discolored or hardened skin on the face, neck, hands, torso, or feet. Morphea is a condition characterized by skin thickening.
The condition, in its most common form plaque, consists of the development of thickened areas of skin, typically on the torso andor limbs. Morphea, also known as localized scleroderma, is an idiopathic inflammatory disorder that causes sclerotic changes in the skin. The prognosis for morphea is good when proper treatment is taken. Genetic and rare diseases information center gard po box 8126, gaithersburg, md 208988126 tollfree. Morphea, also known as localized scleroderma a term that should be discouraged because of unnecessary confusion with scleroderma among providers and patients, is an autoimmune disorder. In fact there are various morphea types, which youll find out it you read more about it. Im creating the datasource in a static block and calling ensureindexes in the same block, but it fails to apply the. Subtypes of morphoea vary according to the location. We need a nonunique key on email because there are literally millions of queries on this field per day, and its a bit slow without the key. Morphea occurs in childhood as well as in adult life. Morphea definition of morphea by medical dictionary.
Morphea symptoms, diagnosis, treatments and causes. In some cases, morphea can be severe, causing significant signs, symptoms, and complications. The four clinical variants include plaquetype morphea, generalized. Werth,md philadelphia, pennsylvania morphea is a rare. Feb 15, 2018 try our interactive tool for help finding information, services, experts, financial aid, and more. But they might also appear on your face, arms or legs. Morphea is a patch of hardened skin that appears spontaneously on any part of the body.
For language access assistance, contact the ncats public information officer. Outcome measures and treatment nicolefett,md,andvictoriap. Mar 08, 2018 morphea is a condition which normally affects the superficial or outermost layer of the skin, although in some cases if these patches appear near the joints, the movement of these joints might be impaired. Currently, uva1 phototherapy is widely recommended as a firstline treatment for morphea, and it is also used for treating wellestablished morphea. The signs and symptoms of morphea can vary greatly from individual to individual. I know how to annotate index on one field on morphia entity, but is there a way to annotate index on compositon of two fields. Genometools the versatile open source genome analysis software. My outer forearms became completely covered by morphea with splotches on my outer upper arms.
We describe a case of morphea who developed inflammatory polyarthritis and sacroiliitis coincident with new skin lesions. Development and initial validation of the localized scleroderma. Picture of morphea late stage morphea is the name for localized patches of scleroderma. Morphea profunda involves deep subcutaneous tissue, including fascia, and there is a clinical overlap with eosinophilic fasciitis, eosinophiliamyalgia syndrome, and the spanish toxic oil syndrome 171. Usually they appear on the trunk, but they can affect any part of the body. In this type of the disorder, the deep subcutaneous tissue. Morphoea american spelling, morphea is characterised by an area of inflammation and fibrosis thickening and hardening of the skin due to increased collagen deposition.
Jun 23, 2011 mind you, not all of these are morphea even though they came up in the morphea search, so to be sure you have to click on each one to go to the page containing them. Morphea medical definition merriamwebster medical dictionary. The lesions are firm but not hard and are usually depressed. Histopathological features in morphea localized scleroderma and. Morphea is a form of scleroderma that is more common in women than men, in a ratio 3. The genometools genome analysis system is a free collection of bioinformatics tools in the realm of genome informatics combined into a single binary named gt. For true indexed collections, please refer to the hibernate annotation extensions. The condition generally lasts several years and then disappears on its own. Your doctor can often diagnose morphea by examination alone, but a biopsy may be needed to confirm. A term used to describe a variety of localized asymmetrical. Morphea, also known as localized scleroderma, is a disorder characterized by excessive collagen deposition leading to thickening of the dermis, subcutaneous tissues, or both.
Jul 07, 2017 morphea is a skin condition that involves a patch or patches of discolored or hardened skin on the face, neck, hands, torso, or feet. Sep 21, 2018 because morphea dries the affected skin, moisturizers may help soften and improve the feel of your skin. Morphea is an uncommon condition that is thought to affect 1 in 100,000 people3. Its pronounced morfeeuh, like metamorphosis or the mighty morphin power rangers.
Compare current morphea drugs and medications with ratings. However morphea can occur in a generalized form as. Patients present with single or multiple inflammatory or sclerotic plaques. Disease bioinformatics research of morphea has been linked to localized scleroderma, scleroderma, sclerosis, diffuse scleroderma, generalized morphea. Over time, the area becomes smooth, shiny, and scarlike. A case report valentina dimitrova, ivelina yordanova, dimitar gospodinov department of dermatology and venereology, medical university pleven, bulgaria journal of imab. Morphea, also called localized scleroderma, is an uncommon skin condition, often persistent, which may appear in various areas of the body. Lesions are usually limited and most commonly just one lesion is found. Aug 07, 20 morphea is a skin disease characterized by local skin inflammation and fibrosis.
Patches most often occur on the abdomen, stomach, and back, and sometimes on the face, arms and legs. The newly validated localized scleroderma cutaneous assessment tool. Localized scleroderma is a rare disease of unknown etiology. Morphea is localized scleroderma confined to the skin. Pending work on annotating a viral genome 1mb and a microsporidian genome 7. This might create confusion in many, since one may not have all of the. Morphea is characterized by skin thickening with increased quantities of collagen in the indurative lesion. Typically, the skin changes appear on the abdomen, chest or back. These texts, dealing with the weapons programs of many nations around the world, were produced for the. Circumscribed scleroderma or morphea is a rare disease that involves limited areas of skin and usually is not associated with visceral lesions.
Morphea is relatively uncommon and women are affected about three times as often as men. The skin becomes firm, stiff, atrophic, and discolored. Morphee is a single pc solution for the automation of the test bed, integration of models in the test bed, and calibration of the engine. Morphea is a skin condition that causes patches of reddish skin that thicken into firm, ovalshaped areas. Over time the patches may become hard, dry and smooth. Morphea is a self limiting condition and resolves on its own in some time, although the chances of recurrence are pretty high and common. Extracutaneous manifestations have been described with this disease including inflammatory arthritis. Morphea genetic and rare diseases information center gard. Morphea american osteopathic college of dermatology aocd. Morphea has been associated with tcell lymphoma in several case reports.
Morphea, also known as localized scleroderma, is a disorder characterized by thickening and induration of the skin and subcutaneous tissue due to excessive collagen deposition. Little is known about morphea since it is a rare, poorly understood, and understudied condition. Morphea is rare in the sense that less than 200,000 people in the u. Morphea is a localized form of scleroderma and affects primarily just the skin.
Linear morphea is the most common subtype of morphea in children. The disorder is more common among women and has no age predilection. Morphea, also called localized scleroderma, is a sclerosing skin disorder that resembles scleroderma systemic sclerosis in terms of cutaneous histopathological features, but differs demographically. Patient and caregiver stories about morphea scleroderma, generalized morphea, localized scleroderma, and juvenile scleroderma. My morphea has spread all over my arms, on my legs, almost my entire back, up my neck and across my hips. Morphea produces reddish, thickened, ovalshaped patches of skin, usually on the chest, stomach, and back.
Morphean is a swiss technology company with a strong presence in more than 12 countries worldwide. Morphea is the name given to localised patches of hardened skin that are smooth and shiny. Morphea is classified into circumscribed, generalized, linear, and pansclerotic subtypes according to the clinical presentation and depth of tissue involvement. Based on an allinone system, numerous configurations are possible. Picture of skin diseases and problems morphea late stage. The localized skin problem is normally categorized into the following groups. Localized scleroderma, outcome measures, damage index. Founded in 2009 and with over 60 partners across europe, the secure morphean platform informs decision making and drives efficiencies for all organisations by generating unique and actionable insights from a multitude of data sources. However the deeper, rapidly spreading forms of morphea require early diagnosis and, if possible, treatment by a scleroderma expert. Apr 16, 2018 morphea, also known as localized scleroderma, is an idiopathic inflammatory disorder that causes sclerotic changes in the skin. May 21, 2018 morphea, also known as localized scleroderma, is a disorder characterized by excessive collagen deposition leading to thickening of the dermis, subcutaneous tissues, or both. Note that it is not necessary to specify an index for a primary key, as the. Some patients with generalized morphea also have a band of thickening on an arm or leg as seen in linear scleroderma, another type of localized scleroderma see below. Sep 21, 2018 morphea is a rare skin condition characterized by small red or purple patches that develop firm white or ivory centers.
Can anyone recommend a reliable genome annotation software. The condition is rare and thought to affect less than 3 out of 100,000 people. Morphea is a rare and incurable autoimmune skin disorder, and its something i have been living with for the last two years. This might create confusion in many, since one may not have all of the signs and symptoms described for the condition. The term scleroderma covers various types of morphoea and systemic sclerosis. Nevertheless, you can see there is a wide variation in what has been described as morphea.
Find a list of current medications, their possible side effects, dosage, and efficacy when used to treat or reduce the symptoms of morphea. Patients present with single or multiple inflammatory or sclerotic. Morphea usually affects only the skin and underlying tissue and, rarely, bone. A condition which is characterized by connective tissue replacement of the skin with firm white patches.
98 1207 1111 1005 1060 444 1339 1190 1428 1136 420 466 1085 1456 1510 1285 736 1592 334 1291 420 323 252 246 1214 787 182 81 1085 1295 1011 870 1268